Two sample MR report
HLA-DQB1_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0713874 | 0.1408794 | 0.6472430 |
| Weighted median | 5 | 0.0472383 | 0.0151559 | 0.0018281 |
| Inverse variance weighted | 5 | 0.0545864 | 0.0115668 | 0.0000024 |
| Simple mode | 5 | 0.0447254 | 0.0215199 | 0.1062234 |
| Weighted mode | 5 | 0.0436379 | 0.0208193 | 0.1041186 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.835395 | 3 | 0.6072631 |
| Inverse variance weighted | 1.849714 | 4 | 0.7633755 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0083937 | 0.0701453 | 0.9123144 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.43e-05 | 0 | TRUE | 0.4220284 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
